ABSTRACT
Objective:To analyze the epidemiological characteristics and drug resistance of Salmonella in patients with food-borne diarrhea in Jiading District. Methods:From January 2018 to December 2019， feces or anal swabs of patients were collected from five hospitals in monitoring sites， and the drug sensitivity test was conducted using the micro broth dilution method. Results:The total detection rate of Salmonella was 7.85% （142/1 810）， and the detection rates of 0-6， 7-17， 18-40， 41-65 and over 65 years old were 8.97% （13/145）， 6.94% （5/72）， 7.58% （75/989）， 8.69% （41/472） and 6.06% （8/132）， respectively. Salmonella rosenbergii was a new dominant serotype in this area. Many strains were resistant to the third and fourth generation cephalosporins， fluoroquinolones and even azithromycin. The sensitivity rate of Salmonella typhimurium to cefotaxime and cefepime was 84.85%， and the resistance rate to fluoroquinolones was 12% to 16%. The mediating rates of Salmonella and Salmonella enteritidis to fluoroquinolones were 56% to 60% and 95.56%， respectively. Conclusion:The detection rate of Salmonella infection is high in all age groups. It is necessary to pay more attention to new dominant serotypes. Salmonella typhimurium is highly resistant to the third and fourth generation cephalosporins and fluoroquinolones， while the sensitivity of Salmonella， especially Salmonella enteritidis to fluoroquinolones has decreased significantly.